Revisiting atenolol as a low passive permeability marker
نویسندگان
چکیده
منابع مشابه
Lactoferrin as a Marker of Systemic Inflammatory Response
Materials and methods. 51 patients, who were ill with generalized peritonitis, went through a prospective randomized research. They were randomized on groups depending on the objective score SAPS (1984): 29 survived people (53%) and 22 people with favorable end (47%). Intensive care and surgical tactics standardized patients. Lactoferrin (LF) as modulator of systemic inflammatory response (SIR)...
متن کاملModeling the pharmacodynamics of passive membrane permeability
Small molecule permeability through cellular membranes is critical to a better understanding of pharmacodynamics and the drug discovery endeavor. Such permeability may be estimated as a function of the free energy change of barrier crossing by invoking the barrier domain model, which posits that permeation is limited by passage through a single "barrier domain" and assumes diffusivity differenc...
متن کاملTheory of Passive Permeability through Lipid Bilayers
Recently measured water permeability through bilayers of different lipids is most strongly correlated with the area per lipid A rather than with other structural quantities such as the thickness. This paper presents a simple three-layer theory that incorporates the area dependence in a physically realistic way and also includes the thickness as a secondary modulating parameter. The theory also ...
متن کاملClara cell protein as a marker of Clara cell damage and bronchoalveolar blood barrier permeability.
The 16 kDa Clara cell protein (CC16), an abundant component of airway secretions, has recently been proposed in humans as a pulmonary marker measurable not only in bronchoalveolar lavage fluid (BALF) but also in serum. The aim of the present study was to investigate the changes and determinants of CC16 concentrations in these fluids in normal rats and rats with lung injury. Female Sprague-Dawle...
متن کاملCapillary-wall collagen as a biophysical marker of nanotherapeutic permeability into the tumor microenvironment.
The capillary wall is the chief barrier to tissue entry of therapeutic nanoparticles, thereby dictating their efficacy. Collagen fibers are an important component of capillary walls, affecting leakiness in healthy or tumor vasculature. Using a computational model along with in vivo systems, we compared how collagen structure affects the diffusion flux of a 1-nm chemotherapeutic molecule [doxoru...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Fluids and Barriers of the CNS
سال: 2017
ISSN: 2045-8118
DOI: 10.1186/s12987-017-0078-x